Ontario Provincial Police (OPP) are investigating after a small plane crashed onto a major highway, sending two people onboard to hospital.

OPP say the Cessna 150 crashed into the centre median of Highway 401 around 8:15 p.m. Monday in front of a rest stop, just west of the Ontario-Quebec border.

They say one person was airlifted to hospital with life-threatening injuries while a second person onboard was sent to hospital by ambulance with non-life-threatening injuries.

Police say the initial investigation suggests the two-seater plane may have experienced a mechanical issue after taking off from a small Quebec airport nearby.

OPP say the plane hit hydro wires before crashing onto the highway.

Police say the Transportation Safety Board of Canada is helping investigate.

This report by The Canadian Press was first published Dec. 6, 2022.