Five teens were seriously injured after a 'targeted' shooting in the area of Black Creek and Trethewey on Wednesday night, Toronto police say.

Emergency crews were called to Clearview Heights, near Trethewey and Black Creek Drives, just after 7:30 p.m. for reports of a shooting.

When officers arrived, they found two victims in a building hallway, Toronto police Chief Mark Saunders told reporters at the scene. Two more victims were located in the vicinity suffering from gunshot wounds.

A fifth victim showed up at a hospital, he said. Three were taken to a trauma centre via an emergency run.

Toronto paramedics said the injuries range from serious to life-threatening.

Saunders said the victims include a 16-year-old girl, a 17-year-old girl, and three males between the ages of 16 and 18.

Preliminary information suggests that a black sedan showed up with three suspects at a building, he said.

The suspects entered the building through a side door and opened fire on the people that were standing in a hallway, Saunders said.

"This was definitely targeted based on the evidence we have," he said.

"They came in, and within a short period of time of coming into the building, they opened that door and fired directly at those people that were standing in the hallway."

Police are looking for three males who are in their late teens and early twenties. They were wearing dark-coloured clothing with hoodies.

They were last seen heading east on Clearview Heights in a dark sedan.

"What my concern is that there are three people right now that have no issue shooting a firearm in the city of Toronto," Saunders said.

Police recovered more than 20 bullet casings from the scene but no weapon was recovered.

He said it is a very solvable case if witnesses come forward and give police any information that can help.

At least 235 people have been shot in the city, the police chief said.

"I haven't seen this number before. We are actively doing our part in making the apprehensions," said Saunders, adding that officers have seized numerous firearms off the streets.

"They're very young people that are shot," Saunders said. "There's no need for this to happen."