NEW YORK (AP) - A poised and confident Alek Manoah dominated the New York Yankees with six innings of two-hit ball to win his major league debut, and the Toronto Blue Jays beat the New York Yankees 2-0 on Thursday in a doubleheader opener.

Marcus Semien and Bo Bichette hit back-to-back homers in the third inning off Domingo German (4-3), and Toronto improved to 6-3 against the Yankees this season by winning the makeup of Tuesday night's rainout.

A 23-year-old right-hander selected 11th in the 2019 amateur draft, Manoah (1-0) was brought up after throwing only 35 professional innings in the minor leagues.

His mother Susana, wearing a white Blue Jays jersey with her son's name and with her son's name on the back, was part of a cheering section that stood out among the sparse crowd for the late-afternoon start and was visible crying when he faced DJ LeMahieu to start his big league career. She later blew her son kisses from the stands.

Manoah, a burly 6-foot-2, 260 pounds, walked LaMahieu on four pitches but then struck out Rougned Odor on three pitches, the last a changeup, then fanned Aaron Judge on a 97.3 mph full-count fastball, his fastest pitch of the game, and retired Gleyber Torres on a flyout.

Manoah allowed singles to Miguel Andujar in the second and fifth inning. He struck out seven and walked two, throwing 60 of 88 pitches for strikes and getting 10 swings and misses. He threw 30 fastballs, 26 sliders, 19 sinkers and 13 changeups.

Jordan Romano worked a 1-2-3 seventh for his second save, finishing a two-hitter in the seven-inning game under pandemic rules. New York did not advance a runner past first base as the Yankees were blanked for the second time this season. Toronto pitched its fourth shutout.

Semien and Bichette gave the Blue Jays a 2-0 lead by hitting 374-foot homers in a four-pitch span.

Semien hit his 13th homer by lining a 2-1 fastball to left and Bichette followed with his 10th by driving a 1-1 changeup to left.

German allowed two runs and three hits in 5 2/3 innings, dropping to 4-1 in seven starts since he was recalled on April 22.

The Yankees lost their second straight after a six-game winning streak.

Jordan Montgomery (2-1) started the second game for the Yankees and Robbie Ray (2-1) for the Blue Jays.

TRAINER'S ROOM

Blue Jays: OF George Springer (strained right quadriceps) caught fly balls and threw to bases. Manager Charlie Montoyo said it was the best Springer has felt since injuring his quad but did not say what the next step would be. Springer has been limited to four games due to the injury. ... RHP Travis Bergen (left shoulder impingement) was placed on the injured list, retroactive to May 24. ... LHP Tommy Milone (shoulder inflammation) was transferred to the 60-day IL. .... RHP Anthony Kay (blister) who was optioned last week to Triple-A Buffalo was placed on the injured list and is expected to start a rehab assignment Sunday.

Yankees: RHP Corey Kluber (sprained right shoulder) was placed on the injured list and was awaiting a second opinion. He exited Tuesday's game with right shoulder tightness and is expected to miss two months. ... 1B Luke Voit (oblique strain) was placed on the injured list. ... DH Giancarlo Stanton (strained left quadriceps) could be activated for Friday's series opener in Detroit. ... LHP Zack Britton (bone spur in left elbow) will start a rehab assignment Saturday for Double-A Somerset. … RHP Luis Severino, who had Tommy John surgery on Feb. 27 last year, threw about 35 pitches to hitters Wednesday and is getting close to starting a minor league rehabilitation assignment. … OF Estevan Florial and RHP Albert Abreu were recalled from Triple-A Scranton/Wilkes Barre to replace Kluber and Voit.

UP NEXT

Blue Jays: LHP Hyun Jin Ryu (4-2, 2.53 ERA) starts Friday's series opener at Cleveland.

Yankees: RHP Gerrit Cole (6-2, 1.81 ERA) starts Friday's series opener at Detroit.