Motorists are being warned about "significant delays" near Exhibition Place this weekend due to a series of road closures to accommodate the Honda Indy, which revs back into town this weekend.

The southbound lanes of Strachan Avenue will be closed from Fleet Street to Lake Shore Boulevard West and Lake Shore Boulevard will be closed in both directions from Strachan Avenue to British Columbia Drive until Sunday, June 14 at midnight.

The city is encouraging anyone planning to attend this weekend's event to take public transit.

The  Ride to Conquer Cancer will close the area bounded by Evans Avenue in the north, The West Mall in the west, Kipling Avenue in the east and Lake Shore Boulevard in the south on Saturday from 6 a.m. to 10 a.m. 

On Sunday, the Festival on Bloor will close Bloor Street from Spadina Avenue to Bathurst Street from 7 a.m. to 8 p.m.

Lansdowne Avenue will also be closed on Sunday in both directions from Bloor Street to College Street starting at 8 a.m. for Portugal Day. The road closure will remain in effect until 1 p.m.

The Toronto Run Challenge will close Wellington Street in both directions from Simcoe Street to John Street on Sunday from 8:30 a.m. to 11 a.m.

A reminder to TTC riders that a portion of the Bloor-Danforth Line will be closed this weekend. No trains will be running between Kennedy and Victoria Park on Saturday, however, regular service will resume Sunday.