A motorcyclist has died following a collision involving another vehicle in Scarborough Wednesday evening, Toronto paramedics have confirmed.

It happened on McCowan Road just north of Highway 401 shortly before 6:30 p.m.

According to police, the motorcyclist was entering onto McCowan Road from Highway 401 when, for unknown reasons, he crossed all the northbound lanes, struck the median, and travelled into the southbound lanes where he was struck.

The male rider, believed to be in his 40s, was pronounced dead at the scene.

The driver of the other vehicle remained on scene, police said.

McCowan Road is currently closed in both directions between Highway 401 and Corporate Drive as police continue to investigate.

The closure is expected to last for several hours, police said.