A man believed to be in his 20s has been taken to a trauma centre in life-threatening condition following an overnight stabbing in the downtown core.

Emergency crews were called to the area of Queen Street West and Spadina Avenue at around 3:30 a.m. on Saturday.

Toronto police said the stabbing took place on a 510 Spadina streetcar.

The male victim was taken from the scene to hospital for treatment, Toronto paramedics said.

No information on any possible suspects wanted in connection with this investigation has been released.

An investigation is underway.